Map of Pancreatica Walks and Runs

Dental disease and pancreatic cancer ?

Three separate studies this year suggest a modest but definite relationship between bacteria that are associated with periodontal / oral disease and pancreatic cancer.

 

The largest published research primarily by European (and some American) researchers reported out recently in the medical journal Gut in a matched control study – found particularly that those with a high level of antibodies against the periodontal bacteria “Porphyromonas gingivalis ATTC 53978” had twice the risk of pancreatic cancer as compared with controls.

 

In May of this year New York University scientists reported in the journal Carcinogenesis a relationship between the bacteria “Porphyromonas gingivalis” and digestive cancers including possibly for pancreatic cancer.

 

And UCLA researchers this April also in Gut found associations between variation in patient salivary bacteria and pancreatic cancer.

 

Not only might this help in further establishing causes for pancreatic cancer, but indicates that saliva may be a good target for trying to find biomarkers for screening and earlier diagnosis.

 

 

 

http://www.ncbi.nlm.nih.gov/pubmed/22990306

http://www.ncbi.nlm.nih.gov/pubmed/22367402

http://www.ncbi.nlm.nih.gov/pubmed/21994333

 

 

Dale O’Brien, MD

Low Adiponectin (fat cell) Hormone Associated with Pancreatic Cancer Risk

Harvard researchers led by Ying Bao, MD, ScD (Brigham and Women’s Hospital and Harvard Medical School) published an article last week in the Journal of the National Cancer Institute with an intriguing finding.  In looking at 468 pancreatic cancer patients against 1080 matched control subjects, they found that the fat cell secreted hormone adiponectin (in serum) was lower in the patient group (6.2 vs. 6.8 µg/mL). This finding held for each of the five groups of patients that they studied.

 

Low adiponectin in blood being associated with higher risk – implies that abnormal glucose and/or fat metabolism may be a contributor to the growth of pancreatic cancer tissue.  The findings of this preliminary study lends itself better understanding the origins of pancreatic cancer, and further research for earlier diagnosis and even treatment.

 

More here

 

Related editorial

 

Dale O’Brien, MD

New Easier BLOD Test to Help Evaluate Carcinoid and Neuroendocrine Tumors

One of the standard tests to try to diagnose carcinoid and neuroendocrine tumors has been the 5-HIAA test – which required a 24-hour sample of urine.  This was often messy, inconvenient, embarrassing, and consequently sometimes inaccurate.

 

The term 5-HIAA stands for 5-Hydroxyindoleacetic acid which is a main metabolite of serotonin – and which is typically found in large quantities in those with tumors such as carcinoid.

 

Researchers from University of Iowa, Eastern Virginia Medical School, and Louisiana State University have developed a blood test that can establish 5-HIAA plasma levels.  Further, they found that this fasting 5-HIAA blood level is proportionate to the 24-hour urinary levels – giving similar useful clinical information without the hassles of the urine test.

 

 

More here

 

 

 

Dale O’Brien, MD

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