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Category Archives: Pancreatic Cancer

FOLFIRINOX as Neoadjuvant Therapy for Cancer of the Pancreas

The idea behind treating surgically unresectable and borderline resectable pancreatic cancer with chemotherapy or chemoradiation is that some minority of cases will thereupon improve to the point of now being deemed amenable to surgery, with its typically more favorable outcome.  This is generally the point then of so-called neoadjuvant therapy. As the 5-FU based four-drug […]

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Biomarker miR-10b for Cancer of the Pancreas: earlier diagnosis and/or therapeutic target?

As alluded to in another recent blog entry, the study of microRNA has been a source of great interest as to the possible development of biomarkers that may screen or aid on the diagnosis of pancreatic cancer.  MicroRNAs (or sometimes abbreviated miR) are small (18 to 25 nucleotide) non-coding RNA molecules that are involved in […]

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SOX Chemo Regimen as 2nd Line for Cancer of the Pancreas

Acronyms in medicine are often a hoot.  We have the four-drug combination called FOLFIRINOX.  Recently, here at Pancreatica we reported on a study of a three-drug version of the above termed: OFF.   Now comes a review of the regimen of S-1 plus oxaliplatin by Japanese researchers, which combination they term: SOX.  In a sense SOX […]

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