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PANCREATIC CANCER PROGNOSIS & SURVIVAL

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Each year more than 60,000 people in the United States (and double this number in Europe) are now diagnosed with pancreatic cancer (adenocarcinoma). The prognosis is such that most of these people will have passed by the end of the first year. In the U.S., pancreatic cancer is approximately the 11th most commonly diagnosed cancer (depending on gender), but the third leading cause of cancer death in men and women.

The prognosis of pancreatic cancer (adenocarcinoma of the pancreas) is a very tough, though the survival rates have been incrementally improving particularly over the past ten to fifteen years. It is important to realize that each person is individual; each cancer is different. Statistics can only indicate what tends to happen in the aggregate, and not in the case of an individual person.

The median survival duration from the time of diagnosis until demise is arguably the worst of any of the cancers – certainly of the major cancers. The median survival for untreated advanced pancreatic cancer is about 3 1/2 months; with good treatment this increases to about about threefold, though many will live much longer. We have encountered  eleven and twelve  year survivors.

Perhaps it is a good place to discuss what the term median means. Simply put, the median is the time point that separates half of patients who live longer from the half who will live less. Thus, there are many patients who will live much longer than the median.

The overall five-year relative survival rate for pancreatic cancer is approximately 14%. For patients with metastatic disease, median survival with modern chemotherapy is generally around 8–11 months. Patients with locally advanced, unresectable disease may experience median survival of approximately 15–20 months with treatment. Following successful surgical resection, selected patients receiving modern adjuvant chemotherapy have achieved median survival exceeding four years in clinical trials.
 
Again, it is imperative to understand that each person’s situation is individual; each cancer is different. Statistics can only indicate what tends to happen in the aggregate, and not in the case of an individual person. Many people do better than average.

Patients with neuroendocrine tumors tend to have a much more favorable prognosis than, for example, those with adenocarcinoma of the pancreas. The natural history of neuroendocrine tumors, islet cell tumors, and carcinoid tumors tends to be very different than that of pancreatic adenocarcinoma. For example, the median survival duration from the time of diagnosis for patients with non-functioning metastatic islet cell tumors may approach up to five years.

pancreatic cancer research

ABSTRACTS:

The following are descriptions of titles of abstracts of medical journal articles that may be interesting or useful to those who are interested in further information about this topic. These abstracts can be searched Here.

Prognostic factors for those treated with Gemzar
Prognosis schema for advanced pancreatic cancer
Standard factors for prognosis in pancreatic cancer surgery
mRNAs for prognosis of cancer of the pancreas
Long Duration Survivors with Cancer of the Pancreas – Are they There?
Prognosis of Early Stage Cancer of the Pancreas
Prognostic Advantage of Ajduvant Treatment of Pancreatic Adenocarcinoma
Resection and Prognosis of Pancreatic Tumors
Treatment and Prognosis of Cancer of the Pancreas
Prognosis of Pancreatic Cancer – the Chemoradiotherapy Controversy
Gemcitabine vs. FOLFIRINOX Regimens: Prognosis
Chemoradiation Plus Induction Chemo for Locally Advanced Cancer of the Pancreas
Survival Statistics for Neoadjuvant Therapy
Prognosis of IPMN
The Promise of FOLFIRINOX: Improved prognosis
Better Prognosis: 5-FU Combination Therapy